研究人员在11月在线出版的《自然—医学》期刊上报告说，他们鉴别出一种新的内分泌激素通道，显示一种促炎症细胞因子在代谢平衡中发挥了正面作用。新结果表明组织间的对话满足了迫切的能量需求，也提出II型糖尿病治疗的新途径。
蛋白白细胞介素-6（IL-6）是一种促炎细胞因子，尽管有争议，但它被认为有害于新陈代谢的平衡，特别是在糖尿病患者体内它的水平出现了升高现象。
Helga Ellingsgaard和同事发现，因运动而在肌肉中所释放的IL-6提高了肠细胞和胰腺α细胞中蛋白质激素GLP- 1的表达。科学家们已经知道，GLP- 1提高了胰腺中胰岛素的分泌，胰岛素促成了细胞对葡萄糖的吸收。因此，GLP- 1水平的提高应该成为满足身体燃料需求的一种方法。（生物探索）
相关英文论文摘要：
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
Exercise, obesity and type 2 diabetes are associated with elevated plasma concentrations of interleukin-6 (IL-6). Glucagon-like peptide-1 (GLP-1) is a hormone that induces insulin secretion. Here we show that administration of IL-6 or elevated IL-6 concentrations in response to exercise stimulate GLP-1 secretion from intestinal L cells and pancreatic alpha cells, improving insulin secretion and glycemia. IL-6 increased GLP-1 production from alpha cells through increased proglucagon (which is encoded by GCG) and prohormone convertase 1/3 expression. In models of type 2 diabetes, the beneficial effects of IL-6 were maintained, and IL-6 neutralization resulted in further elevation of glycemia and reduced pancreatic GLP-1. Hence, IL-6 mediates crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand. This previously unidentified endocrine loop implicates IL-6 in the regulation of insulin secretion and suggests that drugs modulating this loop may be useful in type 2 diabetes.
英文论文链接：https://www.nature.com/nm/journal/v17/n11/full/nm.2513.html
