你有多擅长控制自己的思想？精神控制训练有助于改善帕金森患者的症状。深度大脑刺激包括电极植入大脑有助于缓解帕金森患者的行动难题。
英国加迪夫大学的David Linden说，如果植入电极有效果的话，那么训练大脑进行自我调节也能起一定作用。
为了证实这一观点， Linden的小组让10名帕金森患者想象有关运动的情景，同时对他们的大脑进行为时45分钟的扫描。其中5名接收到实时神经反馈，显示了他们激活大脑某个控制运动区域的能力。所有参加者然后被要求在家也进行这样的训练。
两个月后，与那些没有接受到神经反馈的患者相比，受到神经反馈的患者运动问题（包括肌肉硬度和震颤）都改善了37%。“往通常已经丧失输入的大脑区域传递信号能够重塑神经网络”Linden说。
剑桥大学的神经系统科学家Roger Barker表示表示这种疗法并不是对所有帕金森患者有效，如果患者震颤很严重，那么就很难得到图像，而且有些患者不喜欢核磁扫描。
但是他赞成这个技术对有些患者是个不错的选择，特别是年轻的患者。年轻患者不喜欢服用帕金森药物，因为药物长期服用有副作用，比如行动不能自主和行为异常，非药物的治疗方法是比较好的。（生物探索译）
相关英文论文摘要：
Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Treatment of Parkinson's Disease
Self-regulation of brain activity in humans based on real-time feedback of functional magnetic resonance imaging (fMRI) signal is emerging as a potentially powerful, new technique. Here, we assessed whether patients with Parkinson's disease (PD) are able to alter local brain activity to improve motor function. Five patients learned to increase activity in the supplementary motor complex over two fMRI sessions using motor imagery. They attained as much activation in this target brain region as during a localizer procedure with overt movements. Concomitantly, they showed an improvement in motor speed (finger tapping) and clinical ratings of motor symptoms (37% improvement of the motor scale of the Unified Parkinson's Disease Rating Scale). Activation during neurofeedback was also observed in other cortical motor areas and the basal ganglia, including the subthalamic nucleus and globus pallidus, which are connected to the supplementary motor area (SMA) and crucial nodes in the pathophysiology of PD. A PD control group of five patients, matched for clinical severity and medication, underwent the same procedure but did not receive feedback about their SMA activity. This group attained no control of SMA activation and showed no motor improvement. These findings demonstrate that self-modulation of cortico-subcortical motor circuits can be achieved by PD patients through neurofeedback and may result in clinical benefits that are not attainable by motor imagery alone.
英文论文链接：https://www.jneurosci.org/content/31/45/16309.abstract?sid=8c96fc1b-61fe-4051-913c-2fc7f09679d4
