一项研究发现Tyk2蛋白高表达有助于抑制乳腺癌细胞的生长和转移，这项发现或将为乳腺癌的治疗提供新靶点。研究结果刊登在《Journal of Interferon & Cytokine Research》上。
乳腺癌细胞
弗吉尼亚联邦大学的张启芳和Andrew Larner等同事联合多所大学研究发现，缺少酪氨酸激酶的乳腺癌小鼠体内癌细胞生长和转移速度快于Tyk2水平正常的小鼠。
研究人员推断体内Tyk2的水平影响着动物免疫系统对抗癌细胞的能力，并且在实验中证明了这个观点，论文也描述了Tyk2在免疫相关信号传导通路中的作用。
《Journal of Interferon & Cytokine Research》的主编Ganes C. Sen博士说，这项研究表明Tyk2蛋白的激活有助于抑制癌细胞的生长。（生物探索 millie）
相关英文论文摘要：
The Role of Tyk2 in Regulation of Breast Cancer Growth
The antigrowth and immunomodulatory actions of interferons (IFNs) have enabled these cytokines to be used therapeutically for the treatment of a variety of hematologic and solid malignancies. IFNs exert their effects by activation of the Jak/Stat signaling pathway. IFNγ stimulates the tyrosine kinases Jak1 and Jak2, resulting in activation of the Stat1 transcription factor, whereas type 1 IFNs (IFNα/β) activate Jak1 and Tyk2, which mediate their effects through Stat1 and Stat2. Disruption in the expression of IFNγ, IFNα receptors, or Stat1 inhibits antitumor responses and blunt cancer immunosurveillance in mice. Mutations in Jak2 or constitutive activation of Jak1 or Jak2 also promote the development of a variety of malignancies. Although there are data indicating that Tyk2 plays a role in the pathogenesis of lymphomas, the effects of Tyk2 expression on tumorigenesis are unknown. We report here that Tyk2(-/-) mice inoculated with 4T1 breast cancer cells show enhanced tumor growth and metastasis compared to Tyk2(+/+) animals. Accelerated growth of 4T1 cells in Tyk2(-/-) animals does not appear to be due to decreased function of CD4(+), CD8(+) T cells, or NK cells. Rather, the tumor suppresive effects of Tyk2 are mediated at least in part by myeloid-derived suppressor cells, which appear to be more effective in inhibiting T cell responses in Tyk2(-/-) mice. Our results provide the first evidence for a role of Tyk2 in suppressing the growth and metastasis of breast cancer.
