摘要：一项小鼠研究发现，类似于在人参中发现的一种化学物质的合成化合物可能有助于缓解某些癌症疗法的副作用。
在一些研究报告了人参提取物对癌症疗法副作用的防护效应之后，Samuel J. Danishefsky及其同事合成了一系列类似于人参炔三醇的化合物，这是一种人参提取物的活性成分，然后测试了它们抵消小鼠化疗或放疗的副作用的能力，这些小鼠被移植了人类乳腺或结肠肿瘤。这组作者报告说，这些很容易用商品原材料以较高产率制造的化合物能减少抗癌药紫杉醇带来的外周神经损伤和恶心引起的体重下降。
此外，这些化合物能减少对红细胞和白细胞的损伤——这是抗癌药5-氟脲嘧啶的一种常见副作用，可能导致感染和贫血。
此外，在接受辐射前为这些小鼠注射这些合成化合物也可以减少辐射引起的体重减少和血细胞损伤。在能够进行临床测试之前，需要对这些化合物的化学结构进行优化，但是人参炔三醇可能被证明是辅助癌症治疗的一种在临床上可行的选项。
PNAS：人参成分的化合物可能有助于让癌症治疗更容易
生物探索推荐英文论文摘要：
Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol
Abstract
We describe herein the discovery of a series of panaxytriol (PXT)-derived polyacetylene small molecules with promising cytoprotective activity. In mouse xenograft models, we have demonstrated the capacity of our synthetic analogs to mitigate a range of cancer therapeutic agent-induced toxicities, including body weight loss, lethality, neurotoxicity, and hematotoxicity. Our PXT analogs have also been found to reduce radiation-induced body weight loss and lethality in mouse models. Moreover, several PXT analogs appear to exhibit moderate in vivo antiinflammatory activity as well as in vitro immunoenhancing capabilities. These compounds appear to derive their activity through induction of cancer preventive phase 2 enzymes. The studies described herein suggest that coadministration of a PXT-derived agent with cancer chemotherapeutics or radiation therapy may serve to mitigate a range of therapy-associated toxicities.
