一项新研究综合分析了一组来源人体的抗体，这些抗体可以解除一系列HIV病毒的武装。 尽管这些抗体在自然状态下仅仅出现于小型HIV感染群体中，但新的发现表明，这些广谱性中和抗体在这类病人中要比过去认为的更常见，并具有重要的相似性和高效性。
Johannes Scheid 及其他作者表示，这一研究对HIV疫苗研发和HIV治疗来说是一个好消息。 研究人员研发了一种新型、敏感的检测方法，在4名HIV感染者的血清样本中检测抗体，发现他们体内具有高浓度的广谱性中和抗体。 研究人员还克隆了576个新HIV抗体，这些抗体源自于少数生殖系免疫球蛋白基因。
尽管这些抗体经历了广泛的变异，它们在结合病毒的方式上看来是相似的。
杀伤HIV病毒的抗体具有共同来源
生物探索推荐英文摘要
Common origin for HIV-fighting antibodies
Abstract：A new study expands the group of known antibodies from the human body that can disarm a broad spectrum of HIV viruses. Although these antibodies only occur naturally in a small subset of HIV-infected patients, the new findings suggest that these “broadly neutralizing” antibodies are more common in some of these patients than previously thought. They also share key similarities and are potent, with relatively low concentrations required to neutralize the virus. This may be good news for efforts to develop and HIV vaccine that would coax the body to produce such antibodies, or possibly for HIV therapies, suggest Johannes Scheid and coauthors. The researchers developed a new, more sensitive test for identifying antibodies and used it on serum samples from four HIV-infected individuals known to have high levels of broadly neutralizing antibodies. They cloned 576 new HIV antibodies, which were derived from a small number of germ-line immunoglobulin genes. Despite undergoing extensive mutation, these antibodies appear similar in the way they bind to the virus.
