美国一项最新研究成果显示，如果女性怀孕期间心情焦虑和抑郁，孩子出生后患哮喘的几率会明显提高。
这项研究由美国哥伦比亚儿童环境健康中心的研究人员完成，研究涉及279名妇女。在被调查对象中，约70%的母亲承认，她们在怀孕期间曾高度焦虑或抑郁，结果她们的孩子在5岁前都患有哮喘。
研究人员指出，这表明母亲怀孕时的心情好坏，会对孩子呼吸系统产生影响。了解两者之间关系，将有助于医务人员采取更有效的干预措施。
研究人员说，对怀孕期间心情不好的妇女来说，应该密切观察孩子出生后的呼吸状况，然后通过是否存在咳嗽特别是夜间咳嗽等一系列症状判断孩子是否患上哮喘症。
最新研究成果刊登在7月号美国《过敏、哮喘和免疫学记录》杂志上。
如果女性怀孕期间心情焦虑和抑郁，孩子出生后患哮喘的几率会明显提高
生物探索推荐英文论文摘要：
Relationship between maternal demoralization, wheeze, and immunoglobulin E among inner-city children
Background
Prior research has linked maternal prenatal and postnatal mental health with the subsequent development of asthma in children. However, this relationship has not been examined in inner-city African Americans and Hispanics, populations at high risk for asthma.
Objective
To determine the relationship of maternal demoralization with wheeze, specific wheeze phenotypes, and seroatopy among children living in a low-income, urban community.
Methods
African American and Dominican women aged 18 to 35 years residing in New York City (the Bronx and Northern Manhattan) were recruited during pregnancy (n = 279). Maternal demoralization (ie, psychological distress) was measured both prenatally and postnatally by validated questionnaire. Outcomes included wheeze, transient (birth to 2.5 years of age), late onset (3–5 years), and persistent (birth to 5 years of age), evaluated via questionnaire and total and indoor allergen specific IgE (at birth and ages 2, 3, and 5 years). Logistic regression with generalized estimating equations assessed the association of demoralization with wheeze and atopy. Multinomial regression explored associations between demoralization and specific wheeze phenotypes.
Results
Prenatal demoralization significantly predicted overall wheeze (adjusted odds ratio OR, 1.66; 95% confidence interval [CI], 1.29–2.14), transient wheeze (OR, 2.25; 95% CI, 1.34–3.76), and persistent wheeze (OR, 2.69; 95% CI, 1.52–4.77). No association was found between demoralization and IgE after adjustment (total IgE: OR, 1.04; 95% CI, 0.74–1.45; any specific IgE: OR, 0.96; 95% CI, 0.57–1.60).
Conclusions
In this inner-city cohort, prenatal demoralization was associated with transient and persistent wheeze. Understanding how maternal demoralization influences children's respiratory health may be important for developing effective interventions among disadvantaged populations.
