Evidence that human cardiac myocytes divide after myocardial infarction.
N Engl J Med May 24, 2001
... patients who had died 4 to 12 days after infarction. Ten normal hearts were used as controls. Myocytes ... identified; these features demonstrated that there was myocyte proliferation after myocardial infarction. CONCLUSIONS: Our results challenge the dogma ...
Transplanted adult bone marrow cells repair myocardial infarcts in mice.
Ann N Y Acad Sci Jul 18, 2001
... ) were injected into the healthy myocardium adjacent to the site of the infarct. After 9 days the damaged hearts were examined for ... and alpha smooth muscle actin, respectively. No myocardial regeneration was observed in damaged hearts transplanted with Lin ...
Myocardial infarction as a problem of growth control: cell cycle therapy for cardiac myocy
J Card Fail Feb 06, 1997
Pump failure after myocardial infarction ultimately can be ascribed, in large part, to the inability of ventricular muscle to regenerate functional mass through cell proliferation. Recent studies using adenoviral gene transfer have provided direct evidence ...
Cardiomyocyte cell cycle activation improves cardiac function after myocardial infarction.
Cardiovasc Res Dec 14, 2007
... of this cell cycle activation on cardiac function following myocardial infarction (MI). METHODS: MI was induced in transgenic and ... post-MI correlated positively with the presence of newly formed myocardial tissue which was not apparent at 7 days post-MI. ...
Myocardial Infarction Is Coupled with the Activation of Cyclins and Cyclin-Dependent Kinas
Exp Cell Res Aug 07, 1996
... quantity of cdk2 and cdc2 and the level of their kinase activity were also determined. Myocardial infarction was characterized by an increase in cyclins E, A, and B and cdc2 proteins in the surviving myocytes at 1 and 7 days. ...
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