导读：十二指肠溃疡是一种常见的消化系统疾病。东京大学医学研究所副教授松田浩一与爱知县癌症中心合作，发现患十二指肠溃疡的风险与血型有关，O型血的人患的几率是其他血型者的1.4倍。
十二指肠溃疡是一种常见的消化系统疾病。日本研究人员最新发表的一项报告说，患十二指肠溃疡的风险与血型有关，O型血的人患的几率是其他血型者的1.4倍。
东京大学医学研究所副教授松田浩一与爱知县癌症中心合作，分析了2003年以来的7072名十二指肠溃疡患者的资料，结果发现O型血的人患十二指肠溃疡的人数是在日本人最多的A型血人的1.43倍。而B型与AB型血的人患十二指肠的几率基本与A型血相同。
研究小组在新一期《自然—遗传学》杂志上发表的论文认为，血型是由红细胞表面的糖链类型决定的，而十二指肠的细胞内也有相同基因制造的糖链，如果是O型血，导致溃疡的幽门螺杆菌更容易附着在肠细胞上面，损害肠粘膜形成溃疡。
A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population
Chizu Tanikawa,1 Yuji Urabe,1 Keitaro Matsuo,2 Michiaki Kubo,3 Atsushi Takahashi,3 Hidemi Ito,2 Kazuo Tajima,2 Naoyuki Kamatani,3 Yusuke Nakamura1 & Koichi Matsuda1
Through a genome-wide association analysis with a total of 7,035 individuals with duodenal ulcer and 25,323 controls from Japan, we identified two susceptibility loci at the PSCA gene (encoding prostate stem cell antigen) at 8q24 and at the ABO blood group locus at 9q34. The C allele of rs2294008 at PSCA was associated with increased risk of duodenal ulcer (odds ratio (OR) = 1.84; P = 3.92 × 10−33) in a recessive model but was associated with decreased risk of gastric cancer (OR = 0.79; P = 6.79 × 10−12), as reported previously1. The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10−10). Our findings demonstrate a role for genetic variants in the pathogenesis of duodenal ulcer.
文献链接：https://www.nature.com/ng/journal/vaop/ncurrent/full/ng.1109.html
