细胞凋亡是细胞的一种基本生物学现象，在多细胞生物去除不需要的或异常的细胞中起着必要的作用。凋亡是多基因严格控制的过程。这些基因在种属之间非常保守，如Bcl-2家族、caspase家族、癌基因如C-myc、抑癌基因P53等，随着分子生物学技术的发展对多种细胞凋亡的过程有了相当的认识，但是迄今为止凋亡过程确切机制尚不完全清楚，而凋亡过程的紊乱可能与许多疾病的发生有直接或间接的关系，如肿瘤、自身免疫性疾病等；
细胞凋亡PCRArray可以测定三百多个与细胞凋亡、程序性死亡相关的关键基因的表达谱，其中包括TNF结构域家族；TNF受体家族；Bcl-2和BAG结构域家族；BIR结构域家族；CARD家族；死亡结构域家族；Caspase 家族；抗凋亡基因；促凋亡基因等，这些基因涉及以下几种功能：凋亡、通过死亡结构域受体诱导凋亡或抗凋亡、DNA损伤、氧化应激以及细胞内和细胞外信号转导。
活动内容：800元/样，检测84个凋亡相关功能基因
检测样品类型：组织 细胞，RNA,CDNA
种属类型：人
样品数量不限
联系地址：上海市嘉定区城北路1355号A幢901室
联系人：章经理
电话：15021394887 02163935065
网站：www.wcgene.com
检测基因列表：
Induction of Apoptosis:
Death Domain Receptors: CRADD, FADD, TNF, TNFRSF10B (DR5).
DNA Damage: ABL1, CIDEA, CIDEB, TP53, TP73.
Extracellular Signals: CFLAR (CASPER), DAPK1, TNFRSF25 (DR3).
Other: BAD, BAK1, BAX, BCL10, BCL2L11, BID, BIK, BNIP3, BNIP3L, CASP1 (ICE), CASP10 (MCH4), CASP14, CASP2, CASP3, CASP4, CASP6, CASP8, CD27 (TNFRSF7), CD70 (TNFSF7), CYCS, DFFA, DIABLO (SMAC), FAS (TNFRSF6), FASLG (TNFSF6), GADD45A, HRK, LTA (TNFB), NOD1 (CARD4), PYCARD (TMS1/ASC), TNFRSF10A, TNFRSF9, TNFSF10 (TRAIL), TNFSF8, TP53BP2, TRADD, TRAF3.
Anti-Apoptosis: AKT1, BAG1, BAG3, BAX, BCL2, BCL2A1 (Bfl-1/A1), BCL2L1 (BCL-X), BCL2L10, BCL2L2, BFAR, BIRC3 (c-IAP1), BIRC5, BIRC6, BNIP2, BNIP3, BNIP3L, BRAF, CD27 (TNFRSF7), CD40LG (TNFSF5), CFLAR (CASPER), DAPK1, FAS (TNFRSF6), HRK, IGF1R, IL10, MCL1, NAIP (BIRC1), NFKB1, NOL3, RIPK2, TNF, XIAP (BIRC4).
Regulation of Apoptosis:
Negative Regulation: BAG1, BAG3, BCL10, BCL2, BCL2A1 (Bfl-1/A1), BCL2L1 (BCL-X), BCL2L10, BCL2L2, BFAR, BIRC2 (c-IAP2), BIRC3 (cIAP1), BIRC6, BNIP2, BNIP3, BNIP3L, BRAF, CASP3, CD27 (TNFRSF7), CD40LG (TNFSF5), CFLAR (CASPER), CIDEA, DAPK1, DFFA, FAS (TNFRSF6), IGF1R, MCL1, NAIP (BIRC1), NOL3, TP53, TP73, XIAP (BIRC4).
Positive Regulation: ABL1, AKT1, BAD, BAK1, BAX, BCL2L11, BID, BIK, BNIP3, BNIP3L, CASP1 (ICE), CASP10 (MCH4), CASP14, CASP2, CASP4, CASP6, CASP8, CD40 (TNFRSF5), CD70 (TNFSF7), CIDEB, CRADD, FADD, FASLG (TNFSF6), HRK, LTA (TNFB), LTBR, NOD1 (CARD4), PYCARD (TMS1/ASC), RIPK2, TNF, TNFRSF10A, TNFRSF10B (DR5), TNFRSF25 (DR3), TNFRSF9, TNFSF10 (TRAIL), TNFSF8, TP53, TP53BP2, TRADD, TRAF2, TRAF3.
DEATH Domain Proteins: CRADD, DAPK1, FADD, TNFRSF10A, TNFRSF10B (DR5), TNFRSF11B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25 (DR3), TRADD.
Caspases and Regulators:
Caspases: CASP1 (ICE), CASP10 (MCH4), CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9, CFLAR (CASPER), CRADD, PYCARD (TMS1/ASC).
Caspase Activators: AIFM1 (PDCD8), APAF1, BAX, BCL2L10, CASP1 (ICE), CASP9, NOD1 (CARD4), PYCARD (TMS1/ASC), TNFRSF10A, TNFRSF10B (DR5), TP53.
Caspase inhibitors: CD27 (TNFRSF7), XIAP (BIRC4).
公司合作客户文献：
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