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N-氧化氯氮平 Clozapine N-oxide Description 咨询电话 021-60498804
Metabolite of clozapine. It is 5-HT2 serotonin receptor antagonist.
Specifications
Cas No.
34233-69-7
Product ID
HC4759
Product Name
N-氧化氯氮平 Clozapine N-oxide 标准品 5mg 25mg
Formula Wt.
342.82
Melting Point
212.0-214.0
Store Temp
Ambient
References
Lin G et al J Pharm Sci 83:1212-7 (1994).
N-氧化氯氮平 Clozapine N-oxide
References
Li JH, Jain S, McMillin SM, et al. A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo. Endocrinology. 2013 Oct;154(10):3539-51. PMID: 23861369.
Wess J, Nakajima K, Jain S. Novel designer receptors to probe GPCR signaling and physiology. Trends Pharmacol Sci. 2013 Jul;34(7):385-92. PMID: 23769625.
Farrell MS, Pei Y, Wan Y, et al. A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. Neuropsychopharmacology. 2013 Apr;38(5):854-62. PMID: 23303063.
N-氧化氯氮平 Clozapine N-oxide 参考文献
Alvarez-Curto E, Prihandoko R, Tautermann CS, et al. Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL). Mol Pharmacol. 2011 Dec;80(6):1033-46. PMID: 21880827.
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