玉米MADS类转录因子ZmMADS47通过和籽粒重要转录因子Opaque2互作协同调控醇溶蛋白的表达
上海大学的研究人员通过对Opaque2的酵母双杂交(Yeast two-hybrid screening)技术对其互作蛋白进行筛选以及功能分析,从而对Opaque2调控下游基因的表达的理论模型做出了进一步的解释和完善。该研究成果已经被国际著名学术期刊杂志PLOS Genetics接收,即将在线发表。该研究是上海大学通信学院的博士研究生乔祯逸在宋任涛教授和生命学院青年教师祁巍巍博士的指导下完成的。该研究中RNA-Seq服务由上海伯豪生物技术有限公司提供。详细内容:https://www.shbio.cn/news/research/3065.html
孕妇要多补充蛋白质,不然baby肾里的lncRNA会异常
低体重儿是一种常见的疾病,由于宫内生长受限(IUGR)而导致的低出生体重对孩子成年后的高血压和肾脏疾病关系密切。IUGR通常会引起低体重儿的肾元不足,对孩子的成长造成不良影响。低体重儿和肾元不足存在哪些关联呢?本研究从lncRNA的角度出发,研究了他们之间的关系,为我们理解lncRNA的表达与肾元不足的内在联系提供了新的见解。该研究中大鼠全基因组lncRNA表达谱芯片服务由上海伯豪生物技术有限公司提供。详细内容:https://www.shbio.cn/news/research/3070.html
miR-490-3p与结直肠癌转移的关系及相关机制研究
南方医科大学的研究人员通过体内外实验,明确了miR-490-3p与结直肠癌转移的关系及相关机制。该研究成果已经被国际著名杂志Cancer Letters接受,且已在线发表。该研究是南方医科大学的博士研究生郑克鸿和周欣莹在黄宗海教授和基础医学院赵亮教授的指导下完成的。该研究中Affymetrix GeneChip® PrimeView™ Human Gene Expression Array由上海伯豪生物技术有限公司提供。详细内容:https://www.shbio.cn/news/research/3071.html
2016年4月:上海伯豪客户应用案例精选
1 Ge S, Zhang J, Du Y, Hu B, Zhou Z, Lou J.Dynamic changes in the gene expression profile during rat oral carcinogenesis induced by 4‑nitroquinoline 1‑oxide.Mol Med Rep.2016,13(3):2561-9.
2 Li Q, Hu B, Hu GW, Chen CY, Niu X, Liu J, Zhou SM, Zhang CQ, Wang Y, Deng ZF.tRNA-Derived Small Non-Coding RNAs in Response to Ischemia Inhibit Angiogenesis. Sci Rep. 2016,6:20850.
3 Wang Q, An Y, Yuan Q, Qi Y, Ou Y, Chen J, Huang J.Identification of allelic expression imbalance genes in human hepatocellular carcinoma through massively parallel DNA
and RNA sequencing.Med Oncol. 2016,33(4):38.
4 Qiao Z, Qi W, Wang Q, Feng Y, Yang Q, Zhang N, Wang S, Tang Y, Song R.ZmMADS47 Regulates Zein Gene Transcription through Interaction with Opaque2.PLoS Genet. 2016,12(4):e1005991.
5 Zheng K, Zhou X, Yu J, Li Q, Wang H, Li M, Shao Z, Zhang F, Luo Y, Shen Z, Chen F, Shi F, Cui C, Zhao D, Lin Z, Zheng W, Zou Z, Huang Z, Zhao L.Epigenetic silencing of miR-490-3p promotes development of an aggressive colorectal cancer phenotype through activation of the Wnt/β-catenin signaling pathway.Cancer Lett.2016,pii: S0304-3835(16)30174-4.
6 Li XJ, Zhou J, Liu LQ, Qian K, Wang CL.Identification of genes in longissimus dorsi muscle differentially expressed between Wannanhua and Yorkshire pigs using RNA-sequencing.Anim Genet.2016.
7 Chickooree D, Zhu K, Ram V, Wu HJ, He ZJ, Zhang S.A preliminary microarray assay of the miRNA expression signatures in buccal mucosa of oral submucous fibrosis patients.J Oral Pathol Med.2016.
8 Hu C, Cao H, Pan X, Li J, He J, Pan Q, Xin J, Yu X, Li J, Wang Y, Zhu D, Li L.Adipogenic placenta-derived mesenchymal stem cells are not lineage restricted by withdrawing extrinsic factors: developing a novel visual angle in stem cell biology.Cell Death Dis.2016.
9 Liu M, Huang G, Wang TT, Sun X, Yu LL.3-MCPD 1-palmitate induced tubular cell apoptosis in vivo via JNK/p53 pathways.Toxicol Sci.2016.