维生素E是人体必需的营养物质，许多人经常服用维生素E补充剂。但一项最新科研成果显示，滥用维生素E对身体不仅无益，而且可能有害。
以色列特拉维夫大学研究人员在美国新一期《动脉硬化血栓与血管生物学》杂志上发表研究报告说，他们对来自美国、欧洲和以色列的约30万人进行跟踪调查，将服用维生素E的人和不服用维生素E的人进行对比。结果发现，前者的“质量调整生命年”比后者少近4个月。所谓“质量调整生命年”是将不同生活质量的生存年数换算成相当于完全健康的生存年数，是一个用以评价治疗和保健所带来生命质量和数量改变程度的概念。
不过，研究人员指出，这并非意味着每个服用维生素E补充剂的人都会少活4个月。
此前也有研究发现，维生素E补充剂不但没有预防某些疾病的作用，而且可能和降胆固醇药相冲突。研究人员说，如果能从食物中摄取足量的维生素E，服药补充毫无必要。
推荐原始出处：
Arteriosclerosis, Thrombosis, and Vascular Biology. 2009;29:1304.
Decision Analysis Supports the Paradigm That Indiscriminate Supplementation of Vitamin E Does More Harm than Good
Yedidya Dotan; Ilya Pinchuk; Dov Lichtenberg; Moshe Leshno
From the Department of Physiology and Pharmacology (Y.D., I.P., D.L.) and the Faculty of Management and School of Medicine (M.L.), Tel Aviv University, Sackler Faculty of Medicine, Israel.
Objectives― For many years, the prevailing concept was that LDL oxidation plays a central role in atherogenesis. As a consequence, supplementation of antioxidants, particularly vitamin E, became very popular. Unfortunately, however, the major randomized clinical trials have yielded disappointing results on the effects of vitamin E on both mortality and morbidity. Moreover, recent meta-analyses have concluded that vitamin E supplementation increases mortality. This conclusion has raised much criticism, most of it relating to three issues: (1) the choice of clinical trials to be included in the meta-analyses; (2) the end point of these meta-analyses (only mortality); and (3) the heterogeneity of the analyzed clinical trials with respect to both population and treatment. Our goal was to bring this controversy to an end by using a Markov-model approach, which is free of most of the limitations involved in using meta-analyses.
Methods and Results― We used a Markov model to compare the vitamin E supplemented virtual cohorts with nonsupplemented cohorts derived from published randomized clinical trials that were included in at least one of the major meta-analyses. The difference between the virtual supplemented and nonsupplemented cohorts is given in terms of a composite end point denoted quality-adjusted life year (QALY). The vitamin E supplemented virtual cohort had 0.30 QALY (95%CI 0.21 to 0.39) less than the nontreated virtual cohort.
Conclusions― Our study demonstrates that in terms of QALY, indiscriminate supplementation of high doses of vitamin E is not beneficial in preventing CVD. Selective supplementation of vitamin E to individuals under oxidative stress requires further investigation.
Our objective was to reassess the outcome of nondiscriminatory supplementation of vitamin E with respect to its effects on cardiovascular-related events and mortality. Our analysis, applying a Markov model, revealed that supplementing the general public with vitamin E results in loss of quality-adjusted life years.
