剧烈头痛可能会让人痛不欲生——美国一项研究显示，有偏头痛或严重头痛的人，容易有自杀倾向。
研究指出，有偏头痛或严重头痛的人，自杀的概率比其他人高出4倍到6倍。研究人员也发现，头痛与包括羟色胺在内的大脑化学物质有关，而这些物质出现功能障碍与自杀也有关联。
负责这项研究的密歇根州大学的布瑞斯劳说，多项研究发现，患有偏头痛的人自杀率较高。其实，经常剧烈头痛的人也有自杀倾向。两者的不同是，偏头痛有明显的症状，如恶心、呕吐、畏光、畏声等。
研究发表在期刊《头痛》上。研究发现，偏头痛病患者中有将近9%的人说，他们想要自杀，而非偏头痛性严重头痛患者当中，也有10%有过轻生念头。布瑞斯劳指出，剧烈头痛可能导致病患出现忧郁症，这也是头痛患者有自杀倾向的原因。
Migraine Headaches and Suicide Attempt
Naomi Breslau PhD, Lonni Schultz PhD, Richard Lipton MD, Edward Peterson PhD, K.M.A. Welch MB, ChB, FRCP
Background.— Previous cross-sectional studies reported an increased risk of suicide attempt in persons with migraine headache, which was sustained when psychiatric comorbidity was statistically controlled.
Objective.— To estimate the risk of suicide attempt in persons with migraine vs controls with no history of severe headache, using prospective data and validated diagnostic assessment. To examine the specificity of the migraine-suicide attempt risk by comparing it to the risk associated with non-migraine headache of comparable severity and disability.
Methods.— A cohort of persons with migraine (n = 496), non-migraine severe headaches (n = 151), and controls with no history of severe headache (n = 539) was randomly selected from the general community, assessed in 1997 and reassessed 2 years later.
Results.— Persons with migraine had an increased risk of suicide attempt during the 2-year follow-up period, compared with controls. Odds ratio, adjusted for sex, psychiatric disorder, and previous history of suicide attempt at baseline was 4.43 (95% confidence interval [CI] 1.93, 10.2). Persons with non-migraine headache of comparable intensity and disability also had an increased risk of suicide attempt, compared to controls: odds ratio, adjusted for the same covariates, was 6.20 (95% CI 2.40, 16.0). The difference between the 2 estimates was not significant. In the entire sample, headache severity at baseline predicted suicide attempt: a difference of 1 standard deviation (SD) in pain score increased the risk of suicide attempt by 79%, adjusting for sex and psychiatric disorders.
Conclusions.— The results suggest the possibility that pain severity might account in part for the increased risk of suicide attempt associated with migraine.
文献链接：https://onlinelibrary.wiley.com/doi/10.1111/j.1526-4610.2012.02117.x/abstract
