母总是提醒我们要勤洗手，而洗得太干净真的对我们的健康有好处吗？据美国“每日科学”近日报道，美国最新研究发现，抗菌香皂中含有一种名为“三氯生”的化学物质，过多使用抗菌香皂会增加青少年罹患过敏性疾病的风险，并损害成年人的免疫系统。
密歇根大学公共卫生学院副教授艾洛表示：“这项研究发现支持了卫生假设理论，该理论认为生活在非常清洁卫生的环境中减少了我们接触微生物的机会，而这可能会影响人体免疫系统的正常发育。换言之，太爱干净反而更容易让我们生病。”
生物谷推荐原文出处：
Environmental Health Perspectives DOI: 10.1289/ehp.1002883
The Impact of Bisphenol A and Triclosan on Immune Parameters in the US Population, NHANES 2003-2006
Erin M. Rees Clayton, Megan Todd, Jennifer Beam Dowd, Allison E. Aiello
Background: Exposure to environmental toxicants is associated with numerous disease outcomes, many of which involve underlying immune and inflammatory dysfunction.
Objectives: To address the gap between environmental exposures and immune dysfunction, we investigated the association of two endocrine-disrupting compounds with markers of immune function.
Methods: Using data from the 2003-2006 National Health and Nutrition Examination Survey, we compared urinary bisphenol A (BPA) and triclosan with serum cytomegalovirus antibody levels and diagnosis of allergies or hayfever in US adults and children age ≥ 6 years. We used multivariate ordinary least squares linear regression models to examine the association of BPA and triclosan with cytomegalovirus antibody titers, and multivariate logistic regression models to investigate the association of these chemicals with allergy/hayfever diagnosis. Statistical models were stratified by age (&18 years and ≥18 years).
Results: In analyses adjusted for age, sex, race, BMI, creatinine levels, family income, and educational attainment, in the ≥18 age group, higher urinary BPA levels were associated with higher cytomegalovirus antibody titers (p&0.001). In the &18 age group, lower levels of BPA were associated with higher cytomegalovirus antibody titers (p&0.05). However, triclosan, but not BPA, showed a positive association with allergy/hayfever diagnosis. In the under 18 age group, higher levels of triclosan were associated with greater odds of having been diagnosed with allergies or hayfever (p&0.01).
Conclusions: Endocrine-disrupting chemicals like BPA and triclosan may negatively impact human immune function as measured by CMV antibody levels and allergy/hayfever diagnosis, respectively, with differential consequences based on age. Additional studies should be done to investigate these findings.
