美国研究人员最新发明一种粘贴式免疫法。这种方法有望取代注射式免疫，使免疫预防更加安全和便捷。
美国佐治亚理工学院的科研人员7月18日在《自然－医学》(Nature Medicine)杂志网络版上报告说，粘贴式免疫法在实验鼠身上的试验已取得成功。
研究人员解释说，粘贴式免疫法是指在皮肤上贴上一块膏药，膏药里有直径不到1毫米的“超微针”，这些含有免疫药物的“超微针”会缓慢溶解渗入皮肤。整个“注射”过程需要5至15分钟，不会导致流血和疼痛。
研究负责人萨里万说，一旦粘贴式免疫法人体试验成功，传统的注射式免疫法或将被取代。届时，如要预防流感，人们只需到药店买一块膏药，自己往身上一贴即可
原文出处：
Nature Medicine doi:10.1038/nm.2182
Dissolving polymer microneedle patches for influenza vaccination
Sean P Sullivan1,4, Dimitrios G Koutsonanos2,4, Maria del Pilar Martin2, Jeong Woo Lee3, Vladimir Zarnitsyn3, Seong-O Choi3, Niren Murthy1, Richard W Compans2, Ioanna Skountzou2 " Mark R Prausnitz1,3
Influenza prophylaxis would benefit from a vaccination method enabling simplified logistics and improved immunogenicity without the dangers posed by hypodermic needles. Here we introduce dissolving microneedle patches for influenza vaccination using a simple patch-based system that targets delivery to skin's antigen-presenting cells. Microneedles were fabricated using a biocompatible polymer encapsulating inactivated influenza virus vaccine for insertion and dissolution in the skin within minutes. Microneedle vaccination generated robust antibody and cellular immune responses in mice that provided complete protection against lethal challenge. Compared to conventional intramuscular injection, microneedle vaccination resulted in more efficient lung virus clearance and enhanced cellular recall responses after challenge. These results suggest that dissolving microneedle patches can provide a new technology for simpler and safer vaccination with improved immunogenicity that could facilitate increased vaccination coverage.
