“Cell Press Selections”是由Cell出版社推出的一份推荐文章集合手册，集中介绍某个生命科学研究领域的最新进展及突出成果。最值得一提的是，这些文章均可以免费获取。本期Cell聚焦CRISPR，回顾了该技术在不同领域的突出成果，共包括10篇论文。
在过去的两年里，与CRISPR相关的论文超出了650篇，包括通过基因编辑（基因敲除、敲入、抑制、激活）创造具有特定特征或者疾病的动物模型以及在细胞、受精卵中应用CRISPR等。在疾病治疗领域的应用涉及了HIV、疟疾、癌症、肌肉萎缩症等，这些进展都是令人震惊的。
以下就是在这期合集中涉及的10篇论文：
| 序号 | 论文题目 |
| 1 | Development And Applications Of CRISPR-Cas9 For Genome Engineering |
| 2 | To Acquire Or Resist: The Complex Biological Effects Of CRISPR-Cas Systems |
| 3 | CRISPR-Cas Systems: Prokaryotes Upgrade To Adaptive Immunity |
| 4 | Crystal Structure Of Cas9 In Complex With Guide RNA And Target DNA |
| 5 | CRISPR-Mediated Modular RNA-Guided Regulation Of Transcription In Eukaryotes |
| 6 | One-Step Generation Of Mice Carrying Reporter And Conditional Alleles By Crispr/Cas-Mediated Genome Engineering |
| 7 | Generation Of Gene-Modified Cynomolgus Monkey Via Cas9/RNA-Mediated Gene Targeting In One-Cell Embryos |
| 8 | Dynamic Imaging Of Genomic Loci In Living Human Cells By An Optimized CRISPR/Cas System |
| 9 | Highly Efficient Targeted Mutagenesis Of Drosophila With The CRISPR/Cas9 System |
| 10 | An iCRISPR Platform For Rapid, Multiplexable, And Inducible Genome Editing In Human Pluripotent Stem Cells |
点击以下链接可免费查看完整十篇论文
