最新研究证据表明喝咖啡或可预防糖尿病，其中咖啡中的咖啡因起到了主要作用。发表于ACS出版机构的Journal of Agricultural and Food Chemistry杂志最新研究通过首次动物实验证明这种明显的联系。
糖尿病在美国患者过百万，在世界范围内人数也与日俱增。但是，实验室通过动物研究结果很少能用人。日本研究人员桢文彦.崛尾及同事研究结果显示，过去经常饮用咖啡的人2型糖尿病风险降低了。
科学家们通过给实验用老鼠喂咖啡或水的方式来研究糖尿病。研究发现，咖啡可以控制老鼠高血糖，并改善老鼠胰岛素的敏感性，从而降低糖尿病的风险。另外，咖啡还可以引起其他一些有利的改变，比如对脂肪肝治疗有益等。此外，研究者称，在咖啡中咖啡因可能是其中最有效的抗糖尿病因子。
推荐原文出处：
J. Agric. Food Chem. DOI: 10.1021/jf904062c
Coffee and Caffeine Ameliorate Hyperglycemia, Fatty Liver, and Inflammatory Adipocytokine Expression in Spontaneously Diabetic KK-Ay Mice
Rie Yamauchi?, Misato Kobayashi?, Yuji Matsuda?, Makoto Ojika?, Shigeru Shigeoka§, Yuko Yamamoto#, Yoshie Tou#, Takashi Inoue#, Takao Katagiri#, Atsushi Murai? and Fumihiko Horio*?
? Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
§ Department of Advanced Bioscience, Faculty of Agriculture, Kinki University, Nara 631-8505, Japan
# Product Research and Development Department, Pokka Corporation, Aichi 481-8515, Japan
Epidemiological surveys have demonstrated that habitual coffee consumption reduces the risk of type 2 diabetes. The aim of this work was to study the antidiabetic effect of coffee and caffeine in spontaneously diabetic KK-Ay mice. KK-Ay mice were given regular drinking water (controls) or 2-fold diluted coffee for 5 weeks. Coffee ingestion ameliorated the development of hyperglycemia and improved insulin sensitivity. White adipose tissue mRNA levels of inflammatory cytokines (MCP-1, IL-6, and TNFα), adipose tissue MCP-1 concentration, and serum IL-6 concentration in the coffee group were lower than the control group. Moreover, coffee ingestion improved the fatty liver. Caffeine ingestion as drinking water also caused an amelioration of hyperglycemia and an improvement of fatty liver. These results suggest that coffee exerts a suppressive effect on hyperglycemia by improving insulin sensitivity, partly due to reducing inflammatory cytokine expression and improving fatty liver. Moreover, caffeine may be one of the effective antidiabetic compounds in coffee.
