CEBP:感染丙型肝炎者患肾癌风险加倍

2010-04-13 00:00 · rose

据国外媒体4月12日报道,美国亨利福特医院发现,感染丙型肝炎会使人患肾癌的风险增加。 医生们对亨利福特健康体系有关6.7万多名患者的管理数据进行分析,发现从1997年到2008年,有0.6%的丙型肝炎患者发展成肾癌,与之相比,非丙型肝炎患者只有0.3%的人发展成肾癌。排除年龄、性

据国外媒体4月12日报道,美国亨利福特医院发现,感染丙型肝炎会使人患肾癌的风险增加。

医生们对亨利福特健康体系有关6.7万多名患者的管理数据进行分析,发现从1997年到2008年,有0.6%的丙型肝炎患者发展成肾癌,与之相比,非丙型肝炎患者只有0.3%的人发展成肾癌。排除年龄、性别、种族和潜在的肾病后,感染丙型肝炎几乎使人发展成肾癌的风险增加了一倍。

亨利福特医院肝病专科主任,这篇论文的第一作者斯图亚特戈登说:“这些结果显示,丙型肝炎病毒引起的疾病已经超越了肝脏的范围,事实上感染丙型肝炎病毒的大部分肾癌患者,其肝脏受损的程度非常非常小。”该研究成果发表在4月的美国癌症研究学会《癌流行病学:生物标记与预防》(Cancer Epidemiology, Biomarkers " Prevention)杂志上。

研究人员还发现,丙型肝炎病毒阳性患者患癌症的平均年龄,明显比没得丙肝的人患肾癌的年龄更小。通常年龄更大的人易患肾癌。戈登解释说,丙型肝炎的治愈率超过50%,目前的首要问题是开发出更新、更好的治疗方法。亨利福特医院目前正在担任此类研究的部分临床试验工作。

推荐原文出处:

Cancer Epidemiology, Biomarkers " Prevention April 2010 19; 1066 doi: 10.1158/1055-9965.EPI-09-1275

Risk for Renal Cell Carcinoma in Chronic Hepatitis C Infection

Stuart C. Gordon1,4, Dilip Moonka1, Kimberly A. Brown1, Craig Rogers2, Mary Ann Y. Huang1, Neal Bhatt4 and Lois Lamerato3

Authors' Affiliations:1Division of Gastroenterology and Hepatology, and Departments of 2Urology and 3Biostatistics and Research Epidemiology, Henry Ford Hospital; and 4Wayne State University School of Medicine, Detroit, Michigan

Background: Chronic infection with hepatitis C virus (HCV) confers increased risk for chronic renal disease, and numerous reports suggest an association with renal cell carcinoma (RCC), a cancer with rapidly rising global incidence. We sought to determine whether HCV infection confers an increased risk for developing RCC.

Methods: With the use of administrative data from a large, integrated, and ethnically diverse healthcare system, we did a cohort study of 67,063 HCV-tested patients between 1997 and 2006 who were followed for the development of RCC until April 2008.

Results: A search of the health system cancer registry for patients with the diagnosis of kidney cancer showed that RCC was diagnosed in 0.6% (17 of 3,057) of HCV-positive patients versus 0.3% (177 of 64,006) of HCV-negative patients. The mean age at RCC diagnosis was much younger in HCV-positive individuals (54 versus 63; P & 0.001). The univariate hazard ratio for RCC among HCV patients was 2.20 (95% confidence interval, 1.32-3.67; P = 0.0025). In a multivariate model that included the risk factors age, African-American race, male gender, and chronic kidney disease, the overall hazard ratio for RCC among HCV patients was 1.77 (95% confidence interval, 1.05-2.98; P = 0.0313).

Conclusion: Chronic HCV infection confers a risk for the development of RCC.

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