目前市场上使用的医用胶带能很好地将医疗设备黏着在皮肤上，但也经常会在揭下胶带时，造成皮肤组织撕裂等相关损伤。为此，美国布莱根妇女医院的研究人员发明了一种快速释放的新型医用无痛胶带，它的黏附力很强，但却不会在撕除时引发疼痛，并可最大程度地减少新生儿等患者群体的皮肤损伤。相关研究论文发表在美国《国家科学院学报》在线版上。
此次的研究由布莱根妇女医院生物医学工程科室的杰弗里·卡尔普博士等人领导，同时得到了麻省理工学院的罗伯特·朗格博士的帮助。他们基于对儿科医生的全国调查设计出了符合新生儿等群体需要的三层医用无痛胶带，其能在兼顾较强黏着力的同时安全剥离，成为快速释放医用胶带的新典范。
统计数字显示，美国每年约有150万例由医用胶带剥除不力导致的受伤，多数发生于皮肤脆弱的婴儿和老年群体。卡尔普说，虽然现在使用的包括背衬和黏合剂层的胶带不会对成人造成过大的影响，但对于新生儿等群体而言，这种胶带很容易引发他们娇嫩皮肤的严重损伤，甚至形成永久性疤痕。因此，科研团队在背衬和黏合剂层之间增添了各向异性的黏合剂，这意味着这个中间层会根据方向呈现出不同的物理性质，例如顺着木头的纹理进行黏合就要比交叉纹理的黏合效果更好。
研究人员借助激光蚀刻和防黏衬里制成了各向异性界面，使得新型无痛胶带具有较高的抗剪强度和较低的剥离强度，从而能在剥除胶带时完全避免对于皮肤的损害，同时不影响胶带的黏着力。而揭除背衬剩余的黏合剂也能通过手指揉搓轻易除去，可谓是新生儿等患者群体的福音。
Quick-release medical tape
Bryan Laulicht, Robert Langer, and Jeffrey M. Karp
Medical tape that provides secure fixation of life-sustaining and -monitoring devices with quick, easy, damage-free removal represents a longstanding unmet medical need in neonatal care. During removal of current medical tapes, crack propagation occurs at the adhesive–skin interface, which is also the interface responsible for device fixation. By designing quick-release medical tape to undergo crack propagation between the backing and adhesive layers, we decouple removal and device fixation, enabling dual functionality. We created an ordered adhesive/antiadhesive composite intermediary layer between the medical tape backing and adhesive for which we achieve tunable peel removal force, while maintaining high shear adhesion to secure medical devices. We elucidate the relationship between the spatial ordering of adhesive and antiadhesive regions to create a fully tunable system that achieves strong device fixation and quick, easy, damage-free device removal. We also described ways of neutralizing the residual adhesive on the skin and have observed that thick continuous films of adhesive are easier to remove than the thin islands associated with residual adhesive left by current medical tapes.
文献连接：Quick-release medical tape
